Be certain you know how to just take this item and what other medicines you ought to stay away from getting with it. See also Drug Interactions area. Get professional medical assistance without delay if any of those very serious Unwanted effects come about: gradual/shallow respiratory, unconventional lightheadedness, extreme drowsiness/dizziness, problems waking up.
The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and marginally soluble in alcohol.
Extended-term animal experiments have not been performed to evaluate the carcinogenic probable of codeine or of promethazine, nor are there other animal or human information relating to carcinogenicity, mutagenicity, or impairment of fertility Using these brokers.
Concomitantadministration of promethazine solutions with other respiratory depressantshas an Affiliation with respiratory depression, and in some cases Demise, inpediatric clients.
Promethazine and codeine combination is utilised To ease cough, runny or stuffy nose, sneezing, or other indicators a result of allergic reactions or perhaps the common cold.
Codeine has superior antitussive activity, While lower than that of morphine at equivalent doses. It truly is used in preference to morphine, mainly because Unwanted effects are rare at the usual antitussive dose of codeine.
Certain scientific tests to test the action from the drug on parturition, lactation, and improvement of the animal neonate weren't finished, but a basic preliminary review in Promethazine codeine syrup rats indicated no impact on these parameters.
Narcotic analgesics cause histamine launch, which seems to get to blame for wheals or urticaria often noticed at the internet site of injection on parenteral administration.
These children could possibly be specifically sensitive towards the respiratory depressant consequences of codeine which has been swiftly metabolized to morphine. Codeine is contraindicated for submit-operative discomfort administration in these patients (see WARNINGS – Loss of life Associated with Ultra-Quick Metabolism of Codeine to Morphine and CONTRAINDICATIONS). Excessively massive dosages of antihistamines, which includes promethazine hydrochloride, in pediatric individuals may possibly trigger unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric people. In pediatric clients who will be acutely unwell affiliated with dehydration, there is an increased susceptibility to dystonias with the usage of promethazine HCl.
A healthcare Qualified ought to be consulted ahead of getting any drug, switching any diet plan or commencing or discontinuing any study course of cure.
If it is safe to put inside the trash, go ahead and take medication out with the container. Combine the medication with cat litter, dirt, espresso grounds or other unwanted material. Seal the mixture inside of a bag or container. Place it in the trash.
When useful for an prolonged time, this medication might not do the job at the same time and will involve diverse dosing. Speak with your medical doctor if this medication stops Operating perfectly.
The result of promethazine and/or codeine on later development and improvement in the new child is not known.
Problems OF USE: The knowledge Within this database is intended to complement, not substitute for, the expertise and judgment of Health care pros. The data is not really meant to address all attainable employs, Instructions, safeguards, drug interactions or adverse outcomes, nor need to it be construed to point that use of a particular drug is Protected, proper or successful in your case or everyone else.